Intranasal immunization with dry powder vaccines

Intranasal immunization with multivalent group A streptococcal vaccines protects mice against intranasal challenge infections.

We have previously shown that a hexavalent group A streptococcal M protein-based vaccine evoked bactericidal antibodies after intramuscular injection. In the present study, we show that the hexavalent vaccine formulated with several different mucosal adjuvants and delivered intranasally induced serum and salivary antibodies that protected mice from intranasal challenge infections with virulent ...

Mice against Intranasal Challenge Group A Streptococcal Vaccines Protects Intranasal Immunization with Multivalent

Combinations of protein polysaccharide conjugate vaccines for intranasal immunization.

The ability of 2 mutants of heat-labile Escherichia coli enterotoxin (LTK63 and LTR72) to enhance the immunogenicity of 2 protein polysaccharide conjugate vaccines, Neisseria meningitidis group C (MenC) and Haemophilus influenzae type B (Hib), both of which are conjugated to the nontoxic mutant of diphtheria toxin (CRM197), after intranasal (inl) immunization in mice was evaluated. In addition,...

Immunization with Vaccines

World demand for high quality protein foods has stimulated a rapid development of intensive iish culture techniques. Inherent with the intensive rearing of fish are related problems of high loading densities, declining water quality, adequate diets, handling, and disease control. Man has only recently recognized the threat imposed by disease and its limitation on economic development of the aqu...

Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques.

Measles remains an important cause of childhood mortality worldwide. Sustained high vaccination coverage is the key to preventing measles deaths. Because measles vaccine is delivered by injection, hurdles to high coverage include the need for trained medical personnel and a cold chain, waste of vaccine in multidose vials and risks associated with needle use and disposal. Respiratory vaccine del...